Major depressive episodes 10 mg once daily. Max: 20 mg daily. Panic disorder w/ or w/o agoraphobia Initially 5 mg for the 1st wk, subsequently increased to 10 mg daily. Max: 20 mg daily. Social anxiety disorder 10 mg once daily. May be decreased to 5 mg or increased to a max of 20 mg daily, if necessary. Generalized anxiety disorder & obsessive-compulsive disorder Initially 10 mg once daily. Max: 20 mg daily. Elderly (>65 yr) Initially 5 mg once daily. Max: 10 mg daily. Mild or moderate hepatic impairment & poor CYP2C19 metabolizers Initially 5 mg daily for the 1st 2 wk. Max: 10 mg daily.
QT interval prolongation. Do not start treatment in patients under linezolid therapy. Concomitant use w/ omeprazole or cimetidine. Liver problems. Sexual dysfunction. Abnormal bleeding/hemorrhage. Pregnancy & lactation. Elderly ≥65 yr.
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